This study aims to investigate sex differences in the effects of cannabis among regular cannabis users. Participants will receive either THC or a placebo, complete questionnaires, undergo a brain scan, and provide a blood sample for genetic testing. The research focuses on understanding the impact of cannabis in individuals with Cannabis Use Disorder.
This is a randomized, controlled clinical trial investigating the therapeutic potential of cannabinoids for treating veterans who suffer from Post Traumatic Stress Disorder (PTSD) and suicidal ideation. The study aims to evaluate the effects of cannabis on mental health conditions in a military veteran population. This trial is currently recruiting participants.
This study is investigating whether neuroimaging of brain activity related to learning can predict treatment response in adolescents aged 14-17 for cannabis use disorder. Participants will undergo a brain scan, followed by 10 weekly virtual sessions involving self-reporting and drug tests, with incentives for abstinence. The trial is currently recruiting.
This registered trial is investigating whether transcranial direct current stimulation (tDCS) can help reduce cannabis use in 110 patients with co-occurring schizophrenia and cannabis use disorder. The study aims to measure changes in cannabis consumption, craving, addiction severity, schizophrenia symptoms, and overall functioning.
This registered clinical trial is recruiting patients with cancer to evaluate the safety, tolerability, and efficacy of daily oral cannabis over approximately 4 months. The study aims to assess whether cannabis can alleviate cancer and cancer treatment side effects, including pain, nausea, vomiting, appetite, sleep, and overall quality of life. Participants will be randomized to receive either an active cannabis dose or a placebo.
This is an ongoing outpatient clinical trial investigating how repeated administration of cannabidiol (CBD) influences the behavioral effects and pain-relieving properties of cannabis in healthy human volunteers. The study aims to understand CBD's role in moderating cannabis outcomes and abuse liability.
This is an ongoing longitudinal study recruiting medical cannabis users with chronic pain to assess the impact of cannabis use on cognition, neural function, and drug exposure. It will compare outcomes between CBD-dominant and THC-dominant products, evaluating changes in executive functions, learning, memory, white matter microstructure, and functional brain activity over four months. The study is currently recruiting participants.
This registered clinical trial aims to evaluate how different cannabis strains (indica, sativa, or generic) affect human perception, subjective experiences, and objective behavioral outcomes. It seeks to understand the varied effects of these commonly labeled cannabis products on users. The study is currently recruiting participants.
This ongoing study is investigating the impact of cannabis use on brain function in adolescents who also experience depression. It aims to understand the neural and psychiatric consequences of cannabis consumption in this vulnerable population.
This registered trial aims to investigate the impact of acute exercise on cognitive functions and blood markers of brain plasticity in regular chronic cannabis users compared to non-users. The study will assess how the endocannabinoid system responds to exercise, given that chronic cannabis use alters ECS activity. It seeks to understand if exercise-induced increases in endocannabinoids contribute to neurogenesis and other beneficial adaptations.
This registered clinical trial is investigating whether a combined intervention can help young adults who experience problems with alcohol and cannabis use, as well as sleep difficulties, to reduce these issues. The study aims to recruit 800 participants to evaluate the effectiveness of this intervention.
This registered trial is investigating the effect of medical marijuana use, potentially combined with prescription opioid use, on the driving performance of adults aged 50 and older who experience chronic or severe non-malignant pain. It aims to systematically assess driving ability in this demographic, an area currently lacking robust research. The study also seeks to understand how older adults self-regulate their medication use and driving behavior.
This registered clinical trial aims to investigate the genetic factors influencing vulnerability to cannabis use disorder (CanUD) and psychosis, as well as individual responses to cannabinoids and treatments for CanUD. It focuses on understanding the complex genetic relationship between cannabis exposure, CanUD, and schizophrenia. The study is currently recruiting participants to explore these genetic influences.
This registered trial is investigating carcinogen and toxicant exposure in young adults who use both e-cigarettes and cannabis. The study will measure nicotine, cannabis, and toxicant levels in blood and urine, alongside assessing user behaviors. The goal is to understand the impact of co-using these products in this population.
This registered clinical trial aims to investigate the effects of hemp-derived CBD+THC, hemp-derived CBD-THC, or placebo in older adults (over 65) who use cannabis for pain, anxiety, or mood problems. The study seeks to provide data on harm reduction strategies for this growing demographic of cannabis users. It is an 8-week randomized controlled trial.
This is a registered multi-site clinical trial investigating the benefits and harms of cannabis or cannabinoid use in 2000 newly diagnosed cancer patients. The study focuses on patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer undergoing systemic treatments like chemotherapy or immune checkpoint inhibitors.
This is an ongoing Phase 2 clinical trial, MIVetsCan Can-Coach, designed to evaluate the effectiveness of four coaching sessions in assisting Veterans with chronic pain to better utilize their self-selected cannabis products for pain management and associated symptoms. The study is currently recruiting participants.
This study is a registered trial investigating a brief motivational interviewing intervention in primary care. It aims to address cannabis and alcohol use among diverse young people aged 12-17. The trial is currently recruiting participants.
This is a registered, ongoing, randomized controlled trial investigating whether plant-derived cannabidiol (CBD) can reduce cannabis concentrate use, subjective effects of cannabis, or cannabis cravings in regular cannabis concentrate users who are not seeking to quit. Participants will receive either 200mg/400mg of CBD or a placebo daily for four weeks.
This registered trial aims to investigate the potential harm-reducing effects of hemp-derived CBD in young adult cannabis users. Participants will be randomized to receive CBD or placebo, with a focus on their regular cannabis use patterns in a naturalistic setting.
This is an ongoing clinical trial investigating the effects of cannabidiol (CBD) in patients with end-stage metastatic castration-resistant prostate cancer (mCRPC). The primary goal is to see if CBD can reduce opioid use for pain, while also assessing its impact on pain levels, quality of life, physical activity, inflammation, and potential anti-tumor properties. Participants will receive either CBD or a placebo for nine weeks.
This registered trial is investigating the acute effects of a moderate dose of THC on mood and cognitive function in regular cannabis users. Participants will undergo two sessions in a double-blind, placebo-controlled, crossover design, receiving either 20mg THC or placebo via vaporization. The study aims to measure changes in executive functions and emotional responses after cannabis administration.
This registered trial aims to assess the preliminary effectiveness of daily oral cannabis in promoting weight loss among obese individuals. The study is currently recruiting participants to evaluate this intervention.
This registered randomized crossover trial will investigate how 36 regular cannabis consumers self-titrate their THC dose when vaping high-potency cannabis concentrates. It aims to compare subjective, cognitive, physiological, and pharmacokinetic effects across different THC potencies (30%, 60%, 90%) and explore potential sex differences. The study seeks to provide evidence on acute harms associated with concentrates to inform policy decisions regarding their regulation and public health messaging.
This registered clinical trial is investigating whether hemp-derived cannabidiol (CBD), with or without Delta-9-tetrahydrocannabinol (THC), can help reduce cannabis use and symptoms of cannabis use disorder (CUD) in adults. Participants receive either full-spectrum CBD, broad-spectrum CBD, or a placebo, alongside psychotherapy, over an 8-week period with follow-ups.
This registered trial aims to determine if THC-COOH can be detected in the sweat of young children following acute cannabis intoxication. This research seeks to clarify whether sudoral self-contamination affects hair analysis results for prior cannabis exposure in pediatric cases. The findings will help validate the reliability of hair testing in this population.
This registered clinical trial is investigating the feasibility, acceptability, and preliminary efficacy of a digital intervention designed to address co-occurring cannabis use disorder and depression. Participants will be randomized to either a specific digital intervention (AMP-C) or symptom tracking, with outcomes measuring changes in depressive symptoms and cannabis use, alongside usability ratings. The study is currently recruiting participants to assess this novel digital therapeutic approach.
This study aims to determine if pregnenolone can reverse acute cannabis intoxication and its associated symptoms in healthy adults. It is a placebo-controlled, within-subject crossover study currently recruiting participants. The goal is to lay the groundwork for future research into CB1-receptor NAM medications and validate pregnenolone as a treatment.
This registered trial aims to investigate the effects of two types of repetitive transcranial magnetic stimulation (rTMS) on cannabis craving and brain connectivity in individuals with schizophrenia/schizoaffective disorder and healthy cannabis users. It hypothesizes that different brain circuits are involved in cannabis use in these populations. The study seeks to identify brain targets for future treatments to reduce craving and improve cognitive performance.
This study aims to investigate how cannabis-based products affect physiological arousal in healthy volunteers who are experiencing anxiety due to sleep deprivation. It seeks to understand the body's response to these products under such conditions. The study is currently recruiting participants.
Showing 30 of 500